Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial.

Journal article

BACKGROUND: HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa. METHODS: In this open, non-inferiority trial in three centres in Uganda and one in Zimbabwe, 3321 symptomatic, ART-naive, HIV-infected adults with CD4 counts l...

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Authors: Mugyenyi, P; Walker, A; Hakim, J; Munderi, P; Gibb, D

• Publication status: Published
• Journal: Lancet
• Volume: 375
• Issue: 9709
• Pages: 123-131
• Publication date: 2010-01-01
• DOI: 10.1016/s0140-6736(09)62067-5
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Anemia; Adolescent; Disease Progression; Male; Adenine; Aged; HIV-Associated Lipodystrophy Syndrome; Humans; RNA, Viral; Zidovudine; Hemoglobins; HIV-1; Neutrophils; CD4 Lymphocyte Count; Middle Aged; Organophosphonates; Nevirapine; Lamivudine; HIV Infections; DART Trial Team; Viral Load; Drug Monitoring; Urea; Glomerular Filtration Rate; Dideoxynucleosides; Female; Adult; Neutropenia; Anti-Retroviral Agents; Africa; Creatinine