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Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial.

Abstract:

BACKGROUND: HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa. METHODS: In this open, non-inferiority trial in three centres in Uganda and one in Zimbabwe, 3321 symptomatic, ART-naive, HIV-infected adults with CD4 counts l...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
Lancet
Volume:
375
Issue:
9709
Pages:
123-131
Publication date:
2010-01-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:b278def3-4064-4627-a63c-7e8e9ffa62b6
Source identifiers:
422621
Local pid:
pubs:422621

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