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Cooperation of Syd-1 with Neurexin synchronizes pre-with postsynaptic assembly

Abstract:

Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila melanogaster neuroligin (Nlg1, dnlg1) and neurexin (Nrx-1, dnrx) mutants. We show that the presynaptic active zone protein Syd-1 interacts with Nrx-1 to control synapse formation at the Drosophila neuromuscular junction. Mutants in Syd-1 (RhoGAP100F, dsyd-1), Nrx-1 and...

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Publisher copy:
10.1038/nn.3183

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Nature Neuroscience
Volume:
15
Issue:
9
Pages:
1219-1226
Publication date:
2012-09-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:b260bf0f-832f-4e15-8601-c8252c3a583e
Source identifiers:
353190
Local pid:
pubs:353190
Language:
English

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