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Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.

Abstract:

Dehydroquinate synthase (DHQS) has long been regarded as a catalytic marvel because of its ability to perform several consecutive chemical reactions in one active site. There has been considerable debate as to whether DHQS is actively involved in all these steps, or whether several steps occur spontaneously, making DHQS a spectator in its own mechanism. DHQS performs the second step in the shikimate pathway, which is required for the synthesis of aromatic compounds in bacteria, microbial euka...

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Publication status:
Published

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Publisher copy:
10.1038/28431

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Nature
Volume:
394
Issue:
6690
Pages:
299-302
Publication date:
1998-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b24a0fa8-0106-48c6-9cdb-ed251bd1c56e
Source identifiers:
72820
Local pid:
pubs:72820

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