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Thesis

Coarse-grained modelling of DNA and DNA self-assembly

Abstract:

In this thesis I present a novel coarse-grained model of deoxyribonucleic acid (DNA). The model represents single-stranded DNA as a chain of rigid nucleotides, and includes potentials to represent chain connectivity, excluded volume, hydrogen-bonding and base stacking interactions. The parameterization of these interactions is justified by comparing the model's representation of a range of physical phenomena to experimental data. In particular, the geometrical structure and elastic moduli ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Research group:
Oxford Theory of Soft Matter
Oxford college:
Keble College
Role:
Author

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Division:
MPLS
Department:
Physics
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:b2415bb2-7975-4f59-b5e2-8c022b4a3719
Local pid:
ora:6111
Deposit date:
2012-03-08

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