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Journal article

Towards a mechanism of function of the viral ion channel Vpu from HIV-1.

Abstract:

Vpu, an integral membrane protein encoded in HIV-1, is implicated in the release of new virus particles from infected cells, presumably mediated by ion channel activity of homo-oligomeric Vpu bundles. Reconstitution of both full length Vpu(1-81) and a short, the transmembrane (TM) domain comprising peptide Vpu(1-32) into bilayers under a constant electric field results in an asymmetric orientation of those channels. For both cases, channel activity with similar kinetics is observed. Channels ...

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Publication status:
Published

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Journal:
Journal of biomolecular structure and dynamics
Volume:
24
Issue:
6
Pages:
589-596
Publication date:
2007-06-05
DOI:
EISSN:
1538-0254
ISSN:
0739-1102
URN:
uuid:b1f3d959-6bb0-4716-bdda-3e3f63407db9
Source identifiers:
100379
Local pid:
pubs:100379

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