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Minimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein.

Abstract:

We have previously demonstrated, using expressed deletion constructs, that the fourth membrane proximal cysteine-rich repeat of the p55 TNF receptor (TNF-R) is not required for binding of tumour necrosis factor-alpha (TNF) or lymphotoxin-alpha (LT; tumour necrosis factor-beta). We and others have also shown that the soluble p55 TNF-R, rendered dimeric by fusion to an IgG backbone is extremely effective at neutralizing the harmful effects of TNF overproduction, such as in toxic shock. Here we ...

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Publication status:
Published

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Authors


Corcoran, AE More by this author
Scallon, BJ More by this author
Chernajovsky, Y More by this author
Ghrayeb, J More by this author
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Journal:
European cytokine network
Volume:
9
Issue:
3
Pages:
255-262
Publication date:
1998-09-05
EISSN:
1952-4005
ISSN:
1148-5493
URN:
uuid:b1c66963-923c-4e03-944b-2677aadf1456
Source identifiers:
481589
Local pid:
pubs:481589

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