To characterise the efavirenz steady-state pharmacokinetics in African children using model-based approach, quantifying demographic and genotypic effects on the drug’s disposition, and conduct simulations allowing prediction of optimised doses of efavirenz in this population.
We modelled the steady-state population pharmacokinetics of efavirenz in Ugandan and Zambian children using nonlinear mixed-effects modelling. Individual mid-dose efavirenz concen...Expand abstract
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- Lippincott, Williams and Wilkins Publisher's website
- Journal of acquired immune deficiency syndromes (1999) Journal website
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- Walker et al
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- This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
Plasma efavirenz exposure, sex, and age predict virological response in HIV-infected African children.
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