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Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

Abstract:

In recent years, significant advancements have been made in the understanding of the population distributions and dynamic oligomeric states of the molecular chaperone αB-crystallin and its core domain variants. In this work, we provide solution-phase evidence of the polydispersity of αB-crystallin using microfluidic methods, used for separating the oligomeric species present in solution according to their different electrophoretic mobilities on-chip in a matter of seconds. We in particular de...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c9an00382g

Authors


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Role:
Author
ORCID:
0000-0002-5926-3628
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
University College
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Grant:
1510942
Publisher:
Royal Society of Chemistry
Journal:
Analyst More from this journal
Volume:
144
Issue:
14
Pages:
4413-4424
Publication date:
2019-06-19
Acceptance date:
2019-06-02
DOI:
EISSN:
1364-5528
ISSN:
0003-2654
Pmid:
31215547
Language:
English
Keywords:
Pubs id:
pubs:1026856
UUID:
uuid:b17dd80c-64ee-4030-a6b7-311eab5602fd
Local pid:
pubs:1026856
Source identifiers:
1026856
Deposit date:
2020-01-16

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