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Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I

Abstract:

Glyoxalase I (GLO1) is a putative drug target for trypanosomatids, which are pathogenic protozoa that include the causative agents of leishmaniasis. Significant sequence and functional differences between Leishmania major and human GLO1 suggest that it may make a suitable template for rational inhibitor design. L. major GLO1 was crystallized in two forms: the first is extremely disordered and does not diffract, while the second, an orthorhombic form, produces diffraction to 2.0 A. Molecular-r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1107/S174430910502169X

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author

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/Wellcome Trust More from this funder
Publisher:
International Union of Crystallography Publisher's website
Journal:
Acta Crystallographica Section F: Structural Biology Communications Journal website
Issue:
Pt 8
Publication date:
2005-08-01
Acceptance date:
2005-06-06
DOI:
ISSN:
1744-3091
Pubs id:
pubs:659855
URN:
uri:b152c6a7-da4c-4938-af58-b992cfe023ba
UUID:
uuid:b152c6a7-da4c-4938-af58-b992cfe023ba
Local pid:
pubs:659855

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