Journal article
Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I
- Abstract:
- Lay Summary: Killer-cell immunoglobulin-like receptors (KIRs) are critical regulators of natural killer cell function and bind Class I human leukocyte antigen (HLA-I) with varying degrees of peptide-specificity. We developed a novel method to determine KIR—peptide: HLA-C interactions using peptide-exchange technologies. We use these methods to identify novel HLA-C*04:01 presented peptide ligands for activating receptor KIR2DS4.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1093/discim/kyag010
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 301534/Z/23/Z
- Publisher:
- Oxford University Press
- Journal:
- Discovery Immunology More from this journal
- Volume:
- 5
- Issue:
- 1
- Pages:
- kyag010
- Article number:
- kyag010
- Publication date:
- 2026-05-25
- Acceptance date:
- 2026-05-04
- DOI:
- EISSN:
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2754-2483
- ISSN:
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2754-2483
- Language:
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English
- Keywords:
- Source identifiers:
-
4227702
- Deposit date:
-
2026-06-12
- ARK identifier:
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Terms of use
- Copyright date:
- 2026
- Licence:
- CC Attribution (CC BY)
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