Molecular actions of PPARα in lipid metabolism and inflammation

Journal article

Peroxisome proliferator–activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug–drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.

Authors: Bougarne, N; Weyers, B; Desmet, S; Deckers, J; Ray, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Endocrine Reviews
• Volume: 39
• Issue: 5
• Pages: 760-802
• Publication date: 2018-07-17
• Acceptance date: 2018-07-10
• DOI: 10.1210/er.2018-00064
• EISSN: 1945-7189
• ISSN: 0163-769X
• Pmid: 30020428
• Language: English