Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.

Journal article

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.

Authors: Mathieson, I; Munafò, MR; Flint, J

• Publication status: Published
• Journal: Molecular psychiatry
• Volume: 17
• Issue: 6
• Pages: 634-641
• Publication date: 2012-06-01
• DOI: 10.1038/mp.2011.41
• EISSN: 1476-5578
• ISSN: 1359-4184
• Language: English
• Keywords: Gene Frequency; Humans; Genetic Predisposition to Disease; European Continental Ancestry Group; Odds Ratio; Schizophrenia; Polymorphism, Single Nucleotide; Genetic Association Studies; Nerve Tissue Proteins; Genome-Wide Association Study