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Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.

Abstract:

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymo...

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Publication status:
Published

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Publisher copy:
10.1038/mp.2011.41

Authors


Mathieson, I More by this author
Munafò, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Molecular psychiatry
Volume:
17
Issue:
6
Pages:
634-641
Publication date:
2012-06-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:b0d0e05f-9f0d-438a-ae8b-b0fefa991e6d
Source identifiers:
130898
Local pid:
pubs:130898

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