Cyclic alkenylsiloxanes: synthesis and application towards incednam

Thesis

This thesis explores the use of cyclic alkenylsiloxanes in Hiyama cross-coupling reactions for the stereospecific construction of the Z-pentaenyl system of incednam, the aglycon of incednine. The early chapters continue the investigation of the previously developed C6-C13 lynchpin cyclic diethyl alkenylsiloxane, accessed by controlled semi-hydrogenation of alkynylsiloxane. Later chapters discuss the development of a novel strategy to access the more reactive cyclic dimethyl alkenylsiloxanes and their application towards the synthesis of incednam.

Authors: Gudmundsson, H

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford