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Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.

Abstract:

BACKGROUND: Antiglobulin responses are a significant limitation to the repeated use of murine monoclonal antibodies for treatment of transplant rejection. It is hoped that these might be largely overcome by using antibodies genetically engineered to resemble human antibodies. METHODS: We have compared the responses in patients treated with the CD52 monoclonal antibodies CAMPATH-1G (rat IgG2b) or its humanized derivative, CAMPATH-1H (human immunoglobulin G1). RESULTS: A majority of patients (...

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Publication status:
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Authors


Rebello, PR More by this author
Friend, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Transplantation
Volume:
68
Issue:
9
Pages:
1417-1420
Publication date:
1999-11-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:b0b01020-f976-4aee-8cdc-c6b8fcdeedea
Source identifiers:
13999
Local pid:
pubs:13999

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