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The role of protein structural analysis in the next generation sequencing era.

Abstract:

Proteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all known Mendelian diseases, and play an influential role in shaping complex polygenic diseases. Proteins also serve as the predominant target class for the design of small molecule drugs to modulate their activi...

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Publication status:
Published

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Publisher copy:
10.1007/128_2012_326

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Froese, DS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
Journal:
Topics in current chemistry
Volume:
336
Pages:
67-98
Publication date:
2014-01-05
DOI:
EISSN:
1436-5049
ISSN:
0340-1022
URN:
uuid:b07fae8c-58bd-4404-b4df-30c480ddcdfa
Source identifiers:
332891
Local pid:
pubs:332891

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