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A method for fine mapping quantitative trait loci in outbred animal stocks.

Abstract:

High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected in crosses between inbred strains are often caused by numerous linked QTLs, each of small effect. In a study of fearfulness in mice, we have shown it is possible to fine map small-effect QTLs in a genetically heterogeneous stock (HS). This strategy is a powerful general method of fine mapping QTLs, provided QTLs detected in crosses between inbred strains that ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.230304397

Authors


Talbot, CJ More by this author
Collins, AC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
23
Pages:
12649-12654
Publication date:
2000-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b0691478-7b0c-4022-b804-64ed7c4777f1
Source identifiers:
31765
Local pid:
pubs:31765

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