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Large-scale integrated genome-wide RNA sequencing, miRNA array, and genomic analyses to unravel the functionality of genome-wide association results in endometriosis

Abstract:
Around 50% of endometriosis risk is due to genetic factors. Ten genome-wide significant loci have been associated with endometriosis, but most are located in intergenic regions of the genome. To understand how transcriptomic profiles are perturbed by genetic variants, we conducted a transcriptome-wide study of endometrium, fat and endometrial disease tissue from 190 endometriosis cases and 90 controls.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1933719117699773

Authors

More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; BDI-NDM
Role:
Author


Publisher:
SAGE Publications
Host title:
64th Annual Meeting of the Society for Reproductive Investigation (SRI 2017)
Journal:
64th Annual Meeting of the Society for Reproductive Investigation (SRI 2017) More from this journal
Publication date:
2017-03-01
Acceptance date:
2017-01-06
DOI:


Pubs id:
pubs:718598
UUID:
uuid:b05bc0b8-cc3f-4e37-b170-93a7646cc6df
Local pid:
pubs:718598
Source identifiers:
718598
Deposit date:
2018-06-19
ARK identifier:

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