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Journal article

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.

Abstract:

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT) are transcriptional regulators required for efficient expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progression. BET proteins are recruited on transcriptionally active chromatin via their two N-terminal bromodomains (BRD), a protein interaction module that specifically recognizes acetylated lysine residues in histones H3 and H4. Inhibition of the BET-histone interaction results in t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Cancer research
Volume:
73
Issue:
11
Pages:
3336-3346
Publication date:
2013-06-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:b03cee8e-48f8-4aa4-933d-3cdfc0c34fac
Source identifiers:
394924
Local pid:
pubs:394924

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