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11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.

Abstract:

AIMS/HYPOTHESIS: Exposure to excess glucocorticoid is associated with pancreatic beta cell damage and decreased glucose-stimulated insulin secretion (GSIS). Inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) are converted to active cortisol and corticosterone by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which requires NADPH as cofactor, which is generated by hexose-6-phosphate dehydrogenase (H6PDH). We investigated the localisation and activity of 11beta-HSD1 with...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-008-1137-2

Authors


Walker, EA More by this author
Lavery, GG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Stewart, PM More by this author
Journal:
Diabetologia
Volume:
51
Issue:
11
Pages:
2003-2011
Publication date:
2008-11-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:b02f9663-9fe5-493d-b62f-61ba4c4dd7c4
Source identifiers:
482086
Local pid:
pubs:482086

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