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Hormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: primary report from the HOPE-e randomised, placebo-controlled, feasibility study

Abstract:

Background Symptomatic hand osteoarthritis is more common in women than in men, and its incidence increases around the age of menopause, implicating oestrogen deficiency. No randomised controlled trials of hormone replacement therapy (HRT) have been done in people with hand osteoarthritis. We aimed to determine the feasibility and acceptability of a form of HRT (conjugated oestrogens plus bazedoxifene) in post-menopausal women with painful hand osteoarthritis.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2665-9913(22)00218-1

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Research group:
Oxford Clinical Trials Research Unit (OCTRU); Centre for Osteoarthritis Pathogenesis Versus Arthritis
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Research group:
Oxford Clinical Trials Research Unit (OCTRU)
Role:
Author
ORCID:
0000-0002-9710-5866
More by this author
Institution:
Oxford University Hospitals NHS Foundation Trust
Research group:
Physiotherapy Research Unit, Nuffield Orthopaedic Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Research group:
Oxford Clinical Trials Research Unit (OCTRU); Centre for Osteoarthritis Pathogenesis Versus Arthritis
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Research group:
Oxford Clinical Trials Research Unit (OCTRU)
Role:
Author
ORCID:
0000-0003-4618-774X
Publisher:
Elsevier
Journal:
The Lancet Rheumatology More from this journal
Volume:
4
Issue:
10
Pages:
e725-e737
Place of publication:
England
Publication date:
2022-10-01
Acceptance date:
2022-07-13
DOI:
EISSN:
2665-9913
Pmid:
36341025
Language:
English
Keywords:
Pubs id:
1279947
Local pid:
pubs:1279947
Deposit date:
2023-04-18

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