Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1
Background and aims: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with phosphatase regulating activity. The mechanism whereby PHACTR1 influences CAD risk is unknown. We hypothesized that PHACTR1 would be expressed in human cell types relevant to CAD and regulated by atherogenic or genetic factors. Methods and R... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Accepted Manuscript
National Institute for Health Research Oxford Comprehensive Biomedical Research Centre More from this funder
- Copyright holder:
- Reschen et al.
- Copyright date:
- Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.