Prospective study of cancer in patients with hypogammaglobulinaemia.

Journal article

Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.

Authors: Kinlen, L; Webster, A; Bird, A; Haile, R; Peto, J

• Publication status: Published
• Journal: Lancet
• Volume: 1
• Issue: 8423
• Pages: 263-266
• Publication date: 1985-02-01
• DOI: 10.1016/s0140-6736(85)91037-2
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Prospective Studies; Infant, Newborn; Stomach Neoplasms; Male; Prognosis; Child; Child, Preschool; Humans; Aged; Adolescent; Middle Aged; Agammaglobulinemia; Infant; Neoplasms; Adult; Lymphoma; Female