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Biological, preclinical and clinical characteristics of inhibitors of vascular endothelial growth factors.

Abstract:

Vascular endothelial growth factor (VEGF) plays an important role in the pathophysiology of several sight-threatening retinal disorders such as age-related macular degeneration, diabetic macular edema and proliferative diabetic retinopathy. The discovery of anti-VEGF agents has revolutionized our treatment of these conditions. There are 4 anti-VEGF agents that are either approved or in common use in ophthalmology, namely pegaptanib (Macugen, Pfizer), ranibizumab (Lucentis, Novartis), afliberc...

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Publisher copy:
10.1159/000337152

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Volume:
227 Suppl 1
Issue:
SUPPL. 1
Pages:
2-10
Publication date:
2012
DOI:
EISSN:
1423-0267
ISSN:
0030-3755
URN:
uuid:b00439ff-2922-4436-b642-fcdd65032d80
Source identifiers:
325515
Local pid:
pubs:325515

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