Journal article
Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial
- Abstract:
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Background
Sickle-cell disease increases the risk of malnutrition. Low arginine and nitric oxide bioavailability are implicated in morbidity related to sickle-cell disease. Simple interventions are required, especially in low-income settings. We aimed to test the hypotheses that: (1) supplementary arginine, citrulline, and daily chloroquine increase bioavailable arginine and flow-mediated dilatation (FMD; maximal diameter change; FMDmax%), a measure of nitric oxide-dependent endo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 361.8KB, Terms of use)
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- Publisher copy:
- 10.1016/S2352-3026(18)30020-6
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Lancet Haematology More from this journal
- Volume:
- 5
- Issue:
- 4
- Pages:
- e147-e160
- Publication date:
- 2018-03-13
- Acceptance date:
- 2018-01-15
- DOI:
- EISSN:
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2352-3026
- ISSN:
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2352-3026
- Pmid:
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29548623
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:831894
- UUID:
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uuid:afecbb8f-92f1-4b25-924e-9a1c98b6c8ab
- Local pid:
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pubs:831894
- Source identifiers:
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831894
- Deposit date:
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2018-10-02
Terms of use
- Copyright holder:
- Cox et al
- Copyright date:
- 2018
- Notes:
- © The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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