Neuroscience & Neuroimaging Research Collection

Journal article : Review

Intracranial arterial calcification on computed tomography and risk of cognitive impairment or dementia: a systematic review and meta-analysis

Abstract:: Introduction: Coronary arterial calcification on computed tomography (CT), or CT-CAC, is a widely studied risk factor for acute coronary events, but although intracranial arterial calcification on CT brain imaging (CT-IAC) is also a frequent finding in older individuals, there is no consensus on its prognostic significance, particularly whether its presence, severity, or site predict cognitive impairment or dementia. Given the clinical and mechanistic importance of any ass...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Li, K., Osomo, O. A., & Rothwell, P. M. (2026). Intracranial arterial calcification on computed tomography and risk of cognitive impairment or dementia: a systematic review and meta-analysis. Cerebrovascular Diseases.

MLA Style

Li, K, et al. “Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: a Systematic Review and Meta-Analysis.” Cerebrovascular Diseases, 2026.

Chicago Style

Li, K, OA Osomo, and PM Rothwell. 2026. “Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: a Systematic Review and Meta-Analysis.” Cerebrovascular Diseases.
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Files:: Li_et_al_2026_Intracranial_arterial_calcification.pdf

(Preview, Accepted manuscript, pdf, 5.3MB, Terms of use)

Publisher copy:: 10.1159/000551193

Authors

+ Li, K More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Oxford college:: Balliol College
Role:: Author
ORCID:: 0000-0002-7707-3158

+ Osomo, OA More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

+ Rothwell, PM More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Oxford college:: St Edmund Hall
Role:: Author
ORCID:: 0000-0001-9739-9211

Publisher:: Karger Publishers
Journal:: Cerebrovascular Diseases More from this journal
Publication date:: 2026-04-15
Acceptance date:: 2026-02-20
DOI:: 10.1159/000551193
EISSN:: 1421-9786
ISSN:: 1015-9770

Language:: English
Keywords:: intracranial arterial calcification

stroke

dementia

systematic reviews

meta-analysis
Subtype:: Review
Pubs id:: 2382366
Local pid:: pubs:2382366
Deposit date:: 2026-03-03
ARK identifier:: ark:/29072/ora_afe45a9ee39441f6928c767585d2a6ee

Terms of use

Copyright holder:: Li et al.
Copyright date:: 2026
Rights statement:: © 2026 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (https://karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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