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The type 1 insulin-like growth factor receptor pathway.

Abstract:

Research conducted over the past two decades has shown the importance of the type 1 insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to existing forms of cancer therapy. The IGF1R itself has only recently been accepted as a credible treatment target, however, perhaps reflecting the potential problems for drug design posed by normal tissue IGF1R expression, and close homology with the insulin receptor. Currently approximately 12 anti-IGF1R therapeutics a...

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Publication status:
Published

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Authors


Chitnis, MM More by this author
Protheroe, AS More by this author
Macaulay, VM More by this author
Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
14
Issue:
20
Pages:
6364-6370
Publication date:
2008-10-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:afa64f01-0c09-40c2-8840-7b71102486d5
Source identifiers:
199174
Local pid:
pubs:199174

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