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Journal article

Exogenous microparticles of iron oxide bind to activated endothelial cells but, unlike monocytes, do not trigger an endothelial response.

Abstract:

Targeting particles to sites of inflammation is of considerable interest for applications relating to molecular imaging and drug delivery. We and others have described micron-sized particles of iron oxide (MPIO) that can be directed using specific ligands (e.g. antibodies, peptides and oligosaccharides) to bind to mediators of vascular inflammation in vivo. Since leukocyte binding to these molecules can induce changes in the target cell, an outstanding question has been whether the binding of...

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Publication status:
Published online

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Publisher copy:
10.7150/thno.5895

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
Journal:
Theranostics
Volume:
3
Issue:
6
Pages:
428-436
Publication date:
2013-01-05
DOI:
EISSN:
1838-7640
ISSN:
1838-7640
URN:
uuid:af96ca4b-fe09-4930-a51b-2a6409a42bda
Source identifiers:
407598
Local pid:
pubs:407598

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