Journal article
ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants
- Abstract:
- ChAdOx1 nCoV-19 (AZD1222) is a replication-deficient simian adenovirus-vectored vaccine encoding the spike (S) protein of SARS-CoV-2, based on the first published full-length sequence (Wuhan-1). AZD1222 has been shown to have 74% vaccine efficacy against symptomatic disease in clinical trials. However, variants of concern (VoCs) have been detected, with substitutions that are associated with a reduction in virus neutralizing antibody titer. Updating vaccines to include S proteins of VoCs may be beneficial, even though current real-world data is suggesting good efficacy following boosting with vaccines encoding the ancestral S protein. Using the Syrian hamster model, we evaluate the effect of a single dose of AZD2816, encoding the S protein of the Beta VoC, and efficacy of AZD1222/AZD2816 as a heterologous primary series against challenge with the Beta or Delta variant. Minimal to no viral sgRNA could be detected in lungs of vaccinated animals obtained at 3- or 5- days post inoculation, in contrast to lungs of control animals. In Omicron-challenged hamsters, a single dose of AZD2816 or AZD1222 reduced virus shedding. Thus, these vaccination regimens are protective against the Beta, Delta, and Omicron VoCs in the hamster model.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.2MB, Terms of use)
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(Preview, Supplementary materials, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-022-32248-6
Authors
+ National Institute of Health
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- Funder identifier:
- https://ror.org/01cwqze88
- Grant:
- hCoV-19/USA/KY-CDC-2-4242084/2021
+ UK Research and Innovation
More from this funder
- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- MR/W005611/1
+ National Institute of Allergy and Infectious Diseases
More from this funder
- Funder identifier:
- https://ror.org/043z4tv69
- Grant:
- 1ZIAAI001179-01
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 13
- Issue:
- 1
- Article number:
- 4610
- Place of publication:
- England
- Publication date:
- 2022-08-08
- Acceptance date:
- 2022-07-22
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
35941149
- Language:
-
English
- Pubs id:
-
1273367
- Local pid:
-
pubs:1273367
- Source identifiers:
-
W4290630751
- Deposit date:
-
2026-04-01
- ARK identifier:
Terms of use
- Copyright holder:
- van Doremalen et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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