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Journal article

Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.

Abstract:

Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, a...

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Publication status:
Published

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Publisher copy:
10.1007/82_2010_91

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Current topics in microbiology and immunology
Volume:
348
Pages:
1-23
Publication date:
2011-01-01
DOI:
ISSN:
0070-217X
URN:
uuid:af6ad5e1-847f-427a-acd5-039e74f011d0
Source identifiers:
117497
Local pid:
pubs:117497

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