- Abstract:
-
To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 506.7kb)
-
- Publisher copy:
- 10.1038/ng.3667
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 48
- Issue:
- 10
- Pages:
- 1171–1184
- Publication date:
- 2016-09-05
- Acceptance date:
- 2016-08-15
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Pubs id:
-
pubs:634559
- URN:
-
uri:af680707-f9c2-44b5-9be6-9db160a9ba5d
- UUID:
-
uuid:af680707-f9c2-44b5-9be6-9db160a9ba5d
- Local pid:
- pubs:634559
- Paper number:
- 10
- Language:
- English
- Keywords:
- Copyright holder:
- Ehret et al.
- Copyright date:
- 2016
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/ng.3667
Journal article
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
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