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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Abstract:

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ng.3667

Authors


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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Chasman, DI More by this author
More by this author
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Wellcome Trust More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Issue:
10
Pages:
1171–1184
Publication date:
2016-09-05
Acceptance date:
2016-08-15
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:634559
URN:
uri:af680707-f9c2-44b5-9be6-9db160a9ba5d
UUID:
uuid:af680707-f9c2-44b5-9be6-9db160a9ba5d
Local pid:
pubs:634559
Paper number:
10

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