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Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT).

Abstract:

Background

Selective cyclooxygenase-2 inhibitors and conventional non-selective non-steroidal anti-inflammatory drugs (nsNSAIDs) have been associated with adverse cardiovascular (CV) effects. We compared the CV safety of switching to celecoxib vs. continuing nsNSAID therapy in a European setting.

Method

Patients aged 60 years and over with osteoarthritis or rheumatoid arthritis, free from established CV disease and taking chronic prescribed nsNSAIDs, were randomiz...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/eurheartj/ehw387

Authors


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ORCID:
0000-0001-5189-6669
Hawkey, CJ More by this author
More by this author
ORCID:
0000-0002-6317-3975
Scheiman, JM More by this author
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University of Oxford More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
38
Issue:
23
Pages:
1843-1850
Publication date:
2016-10-05
Acceptance date:
2016-08-10
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Pubs id:
pubs:650656
URN:
uri:af570b27-6c82-43a9-b355-919b572066d9
UUID:
uuid:af570b27-6c82-43a9-b355-919b572066d9
Local pid:
pubs:650656
Language:
English
Keywords:

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