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RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II.

Abstract:

Non-canonical pathways of osteoclastogenesis have been described in which several cytokines are able to substitute for RANKL. These cytokines are few in number and their role(s) in pathological bone resorption has not been ascertained. We have identified five additional cytokines, APRIL, BAFF, NGF, IGF I and IGF II, that can induce RANKL-independent osteoclastogenesis. All five cytokines induced both osteoclast differentiation and activation with respect to the formation of significant number...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2010.12.023

Authors


Hemingway, F More by this author
Knowles, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Bone
Volume:
48
Issue:
4
Pages:
938-944
Publication date:
2011-04-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:af43db04-c958-438e-a765-cdf28da9dfca
Source identifiers:
245427
Local pid:
pubs:245427

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