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Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.

Abstract:

AIMS: Some children with malaria and convulsions also have concurrent bacterial meningitis. Chloramphenicol is used to treat the latter whereas phenytoin is used for convulsions. Since chloramphenicol inhibits the metabolism of phenytoin in vivo, we studied the effects of chloramphenicol on phenytoin pharmacokinetics in children with malaria. METHODS: Multiple intravenous (i.v.) doses of chloramphenicol succinate (CAP) (25 mg kg-1 6 hourly for 72 h) and a single intramuscular (i.m.) seizure ...

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Publication status:
Published

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Authors


Newton, CR More by this author
Muchohi, SN More by this author
Otieno, GO More by this author
Kokwaro, GO More by this author
Journal:
British journal of clinical pharmacology
Volume:
54
Issue:
6
Pages:
635-642
Publication date:
2002-12-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:af40e2d8-8f1c-46fc-9cd5-ce6d0c18991d
Source identifiers:
185607
Local pid:
pubs:185607

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