Journal article
Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium
- Abstract:
- We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1093/cercor/bhaa332
Authors
+ European Commission
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- Funder identifier:
- https://ror.org/00k4n6c32
- Grant:
- 732592
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- G1001354
- Publisher:
- Oxford University Press
- Journal:
- Cerebral Cortex More from this journal
- Volume:
- 31
- Issue:
- 4
- Pages:
- 1953-1969
- Publication date:
- 2020-11-25
- Acceptance date:
- 2020-10-12
- DOI:
- EISSN:
-
1460-2199
- ISSN:
-
1047-3211
- Language:
-
English
- Keywords:
- Pubs id:
-
1137639
- Local pid:
-
pubs:1137639
- Deposit date:
-
2020-10-14
- ARK identifier:
Terms of use
- Copyright holder:
- Fjell et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected]
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