Thesis
Mechanisms of radiation leukaemogenesis, characterisation of haematopoietic stem cells and modulation of risk
- Abstract:
-
Haematopoietic bone marrow cells are amongst the most sensitive to ionising radiation (IR), initially resulting in cell death or genotoxicity that may later lead to leukaemia development, most frequently Acute Myeloid Leukaemia (AML). The target cells for radiation-induced Acute Myeloid Leukaemia (rAML) are believed to lie in the haematopoietic stem and progenitor cell (HSPC) compartment. Using the inbred strain CBA/Ca as a murine model of rAML, progress has been made in understanding the ...
Expand abstract
Actions
Authors
Contributors
+ Finnon, R
- Institution:
- UKHSA
- Research group:
- Cancer Mechanisms and Biomarkers
- Role:
- Contributor
+ Badie , C
- Institution:
- UKHSA
- Research group:
- Cancer Mechanisms and Biomarkers
- Role:
- Supervisor
+ Hill, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Sub department:
- CRUK/MRC Ox Inst for Radiation Oncology
- Oxford college:
- Wolfson College
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-02-24
Terms of use
- Copyright holder:
- Karabulutoglu, M
- Copyright date:
- 2023
If you are the owner of this record, you can report an update to it here: Report update to this record