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Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.

Abstract:

Physiological variability manifests itself via differences in physiological function between individuals of the same species, and has crucial implications in disease progression and treatment. Despite its importance, physiological variability has traditionally been ignored in experimental and computational investigations due to averaging over samples from multiple individuals. Recently, modelling frameworks have been devised for studying mechanisms underlying physiological variability in card...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.pbiomolbio.2015.12.002

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Gemmell, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Sánchez, C More by this author
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Engineering and Physical Sciences Research Council More from this funder
China Scholarship Council More from this funder
Natural Sciences and Engineering Research Council of Canada More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Progress in biophysics and molecular biology Journal website
Publication date:
2015-12-14
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
URN:
uuid:aeab84ac-001d-440e-a91a-2c253cbcb232
Source identifiers:
587121
Local pid:
pubs:587121

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