Journal article : Review
Precision Is Not Enough: When Tools Outpace Translation in Ocular Gene Therapy
- Abstract:
- Advances in molecular biology have positioned the eye as a leading platform for gene therapy, owing to its surgical accessibility, relative immune privilege, and the ability of the contralateral eye to serve as an anatomical control. We trace the historical evolution of gene discovery, synthesize current gene therapy strategies for inherited and acquired ocular disorders, critically evaluating the limitations of CRISPR and related genome-editing technologies, and examine the key scientific and translational challenges that must be addressed for genetic therapies to be integrated into routine ophthalmic practice.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.3390/genes17030283
Authors
+ Foundation Fighting Blindness Clinical Research Fellowship
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- Grant:
- CD-CL-0625-0908-OXH
- Publisher:
- MDPI
- Journal:
- Genes More from this journal
- Volume:
- 17
- Issue:
- 3
- Pages:
- 283
- Article number:
- 283
- Publication date:
- 2026-02-27
- Acceptance date:
- 2026-02-24
- DOI:
- EISSN:
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2073-4425
- ISSN:
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2073-4425
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
-
2390823
- Local pid:
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pubs:2390823
- Source identifiers:
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3834422
- Deposit date:
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2026-03-09
- ARK identifier:
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Terms of use
- Copyright date:
- 2026
- Licence:
- CC Attribution (CC BY)
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