Journal article
RD21-like proteases: key effector hubs in plant-pathogen interactions
- Abstract:
- Over the past decades, numerous studies have demonstrated that proteases serve as a crucial regulatory mechanism in controlling plant immunity. In this review, we specifically focus on the role of one subfamily of RD21-like papain-like cysteine proteases that carry a C-terminal granulin domain. These proteases share high homology but have been described under very different names in different plant species. We provide a comprehensive overview of the background, endogenous regulation, and subcellular localization of RD21-like proteases in plants. Notably, RD21-like proteases act in immunity against various pathogens and they are targeted by many unrelated pathogen-secreted effectors that inactivate, mislocalise or degrade RD21-like proteases. We highlight open questions and strategies to use this knowledge to develop innovative strategies for crop protection.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.7MB, Terms of use)
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(Preview, Supplementary materials, pdf, 45.2KB, Terms of use)
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- Publisher copy:
- 10.1093/jxb/erae496
Authors
+ European Research Council
More from this funder
- Funder identifier:
- https://ror.org/0472cxd90
- Grant:
- 101019324
+ Biotechnology and Biological Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/00cwqg982
- Grant:
- BB/Y000560/1
- Publisher:
- Oxford University Press
- Journal:
- Journal of Experimental Botany More from this journal
- Volume:
- 76
- Issue:
- 15
- Pages:
- 4212–4219
- Place of publication:
- England
- Publication date:
- 2024-12-10
- Acceptance date:
- 2024-12-09
- DOI:
- EISSN:
-
1460-2431
- ISSN:
-
0022-0957
- Pmid:
-
39658213
- Language:
-
English
- Keywords:
- Pubs id:
-
2071687
- Local pid:
-
pubs:2071687
- Deposit date:
-
2025-04-29
- ARK identifier:
Terms of use
- Copyright holder:
- Huang and van der Hoorn
- Copyright date:
- 2024
- Rights statement:
- © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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