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Journal article

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

Abstract:

A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion partners that have been reported to reside in one or more poorly defined complexes linked to transcription elongation through interactions with the histone H3-K79 methyltransferase DOT1 and positive transcription elongation factor b (P-TEFb). Here we first identify natural complexes (purified through fusion partners AF9, AF4, and ELL) with overlapping components, diffe...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1111498108

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
38
Pages:
15751-15756
Publication date:
2011-09-06
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ae564911-db31-4ca4-9d9a-ea19080ffac7
Source identifiers:
331898
Local pid:
pubs:331898

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