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Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

Abstract:

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, suggesting selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, we demonstrate that Sl2 and McCb have opposing malaria associations. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/eLife.31579

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Herbert Opi, D
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Funding agency for:
Swann, O
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Funding agency for:
Williams, T
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Funding agency for:
Rowe, A
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2018
Issue:
7
Pages:
Article: e31579
Publication date:
2018-04-25
Acceptance date:
2018-04-01
DOI:
ISSN:
2050-084X
Pubs id:
pubs:833243
URN:
uri:ae4f1a8e-5dde-464f-93d3-3495e31eac11
UUID:
uuid:ae4f1a8e-5dde-464f-93d3-3495e31eac11
Local pid:
pubs:833243

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