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Journal article

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

Abstract:

Thymic T cell development is dependent on a specialized epithelial microenvironment mainly composed of cortical and medullary thymic epithelial cells (TECs). The molecular programs governing the differentiation and maintenance of TECs remain largely unknown. Wnt signaling is central to the development and maintenance of several organ systems but a specific role of this pathway for thymus organogenesis has not yet been ascertained. In this report, we demonstrate that activation of the canonica...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0713723

Authors


Keller, MP More by this author
Hauri-Hohl, M More by this author
Zhanybekova, S More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
182
Issue:
5
Pages:
2997-3007
Publication date:
2009-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:ae10aa7c-d94e-45fd-a8aa-c8a5ba55a944
Source identifiers:
309041
Local pid:
pubs:309041

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