Journal article
Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets
- Abstract:
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Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and to examine the indications for the prescriptions recorded and whether there was contact with secondary care specialists on or around the time of the first antidepressant prescription.
Methods and analysis All eligible CYP aged between 5 and 17 years in 1998–2017 from the QResearch primary care database will be included. Incidence and prevalence rates of any antidepressant prescription in each year will be calculated. We will examine four different antidepressant classes: selective serotonin reuptake inhibitors, tricyclic and related antidepressants, serotonin and norepinephrine reuptake inhibitors and other antidepressants, as well as for individual drugs. Linked primary and secondary care data (hospital episode statistics) in the year before and up to 6 months after the first antidepressant prescription will be examined for CYP whose first antidepressant prescription was in 2006–2017. Whether there were records of indications and being seen by psychiatric or paediatric specialists will be identified. Trends over time and differences by region, deprivation and ethnicity will be examined using Poisson regression.
Discussion This large, population-based study will give an up-to-date picture of antidepressant prescribing in CYP and identify any variation. Understanding what indications are recorded when CYP are being prescribed antidepressants, and whether this was done in partnership with secondary care specialists, will provide evidence of whether appropriate guidelines are being followed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, 250.8KB, Terms of use)
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- Publisher copy:
- 10.1136/ebmental-2019-300097
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- Evidence-Based Mental Health More from this journal
- Volume:
- 22
- Issue:
- 3
- Pages:
- 129-133
- Place of publication:
- England
- Publication date:
- 2019-06-28
- Acceptance date:
- 2019-06-14
- DOI:
- EISSN:
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1468-960X
- ISSN:
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1362-0347
- Pmid:
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31253602
- Language:
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English
- Keywords:
- Pubs id:
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1027911
- Local pid:
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pubs:1027911
- Deposit date:
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2021-06-10
Terms of use
- Copyright holder:
- Jack et al.
- Copyright date:
- 2019
- Rights statement:
- ©2019 Author(s) (or their employer(s)). Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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