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Multiple cascade effects of oxidative stress on astroglia.

Abstract:

Many neurodegenerative diseases share common underlying features, most prominent of which are dysregulation of calcium homeostasis and reactive astrogliosis, ultimately triggered by oxidative stress. Interestingly, an additional feature of the early response to stress conditions is the upregulation and release of acetylcholinesterase (AChE). This study therefore investigates the link between oxidative stress, calcium influx, gene expression, protein synthesis, and AChE release. We report that...

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Publication status:
Published

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Publisher copy:
10.1002/glia.20547

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Glia
Volume:
55
Issue:
13
Pages:
1348-1361
Publication date:
2007-10-05
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
URN:
uuid:adf88e8c-df90-45cd-941e-fd15031b9a07
Source identifiers:
185216
Local pid:
pubs:185216

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