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Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study

Abstract:
In a discovery-replication setting, we identified 57 proteins transethnically associated with eGFR. The revealed causal relationships are an important stepping stone in establishing testican-2 as a clinically relevant physiological marker of kidney disease progression, and point to additional proteins warranting further investigation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1681/asn.2020071070

Authors

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Role:
Author
ORCID:
0000-0002-3906-5405
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Role:
Author
ORCID:
0000-0001-6135-3764
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Role:
Author
ORCID:
0000-0001-6762-2929
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Role:
Author
ORCID:
0000-0002-9132-8030
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Role:
Author
ORCID:
0000-0001-6238-5952


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Funder identifier:
10.13039/501100000291
Grant:
RP_017_20180302
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Funder identifier:
10.13039/501100000274
Grant:
PG/17/35/33001
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Funder identifier:
10.13039/100008982
Grant:
NPRPC11-0115-180010
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Funder identifier:
10.13039/501100004590
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Funder identifier:
10.13039/501100000272


Publisher:
American Society of Nephrology
Journal:
Journal of the American Society of Nephrology More from this journal
Volume:
32
Issue:
7
Pages:
1747-1763
Publication date:
2021-06-16
DOI:
EISSN:
1533-3450
ISSN:
1046-6673


Language:
English
Keywords:
Pubs id:
1197990
Local pid:
pubs:1197990
Source identifiers:
W3168215356
Deposit date:
2026-03-26
ARK identifier:
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