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Journal article : Review

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Abstract:

The precise regulation of gene transcription is required to establish and maintain cell type-specific gene expression programs during multicellular development. In addition to transcription factors, chromatin, and its chemical modification, play a central role in regulating gene expression. In vertebrates, DNA is pervasively methylated at CG dinucleotides, a modification that is repressive to transcription. However, approximately 70% of vertebrate gene promoters are associated with DNA elemen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbagrm.2020.194567

Authors


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Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-8726-7888
Publisher:
Elsevier
Journal:
BBA - Gene Regulatory Mechanisms More from this journal
Volume:
1863
Issue:
8
Article number:
194567
Publication date:
2020-04-29
Acceptance date:
2020-04-22
DOI:
ISSN:
1874-9399
Pmid:
32360393
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1103743
Local pid:
pubs:1103743
Deposit date:
2020-06-05

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