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Evaluating 12 automated, whole-genome sequencing analysis pipelines for Mycobacterium tuberculosis complex: a comparative study

Abstract:
Background
Reliance on complex, custom-built bioinformatics pipelines is a barrier to the implementation of whole-genome sequencing (WGS) of Mycobacterium tuberculosis in high-burden settings in some low-income and middle-income countries (LMICs). Automated analysis pipelines could address this inequity in access to WGS-based diagnostics and surveillance. This study aimed to systematically evaluate the performance and usability of publicly available WGS pipelines... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0002-1584-9141
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author


More from this funder
Funder identifier:
https://ror.org/029chgv08
Grant:
214560/Z/18/Z
214560/Z/18/Z
More from this funder
Funder identifier:
https://ror.org/0187kwz08
Grant:
NIHR200915
More from this funder
Funder identifier:
https://ror.org/04v48nr57


Publisher:
Elsevier
Journal:
Lancet Microbe More from this journal
Volume:
6
Issue:
12
Article number:
101210
Publication date:
2025-10-21
Acceptance date:
2025-07-17
EISSN:
2666-5247


Language:
English
Pubs id:
2258684
Local pid:
pubs:2258684
Deposit date:
2025-07-31
ARK identifier:

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