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The structure of 4-way DNA junctions: specific binding of bis-intercalators with rigid linkers.

Abstract:

During replication and recombination, two DNA duplexes lie side by side. We have developed reagents that might be used to probe structure during these critical processes; they contain two intercalating groups connected by a rigid linker that forces those groups to point in opposite directions. If their stereochemistry proves appropriate, such structure-specific agents should intercalate specifically into adjacent duplexes in the Y- and X-shaped structures (i.e. 3- and 4-way junctions, now kno...

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Publication status:
Published

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Publisher copy:
10.1093/nar/24.9.1594

Authors


Carpenter, ML More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nucleic acids research
Volume:
24
Issue:
9
Pages:
1594-1601
Publication date:
1996-05-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:adcc1f72-a000-4358-8171-ac718994d8b7
Source identifiers:
10985
Local pid:
pubs:10985

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