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Journal article

Gestational stress induces the unfolded protein response resulting in heart defects

Abstract:

Congenital heart disease (CHD) is an enigma. It is the most common human birth defect and yet, even with the application of modern genetic and genomic technologies, only a minority of cases can be explained genetically. This is because environmental stressors also cause CHD. Here we propose a plausible non-genetic mechanism for induction of CHD by environmental stressors. We show that exposure of mouse embryos to short-term gestational hypoxia induces the most common types of heart defect. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.136820

Authors


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Grant:
OfficeofHealth
MedicalResearch
More from this funder
Grant:
APP1019776
1074386
Senior Research Fellowship 1042002 (SLD
Chain Reaction More from this funder
Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
143
Issue:
14
Pages:
2561-2572
Publication date:
2016-01-01
Acceptance date:
2016-05-20
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Source identifiers:
624038
Pubs id:
pubs:624038
UUID:
uuid:adbb1b89-52e4-4d38-a971-6274742f59bb
Local pid:
pubs:624038
Deposit date:
2016-05-26

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