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Journal article

Cholinergic deficits contribute to behavioral disturbance in patients with dementia.

Abstract:

BACKGROUND: Noncognitive behavioral changes such as depression, aggressive behavior, psychosis, and overactivity occur frequently in patients with dementia, in addition to cognitive impairment, and often determine the need for institutionalization. The biochemical basis of such changes is poorly understood. Clinical trial data indicate that cholinomimetics improve noncognitive behaviors. This study investigated the relationship between markers of the cholinergic and dopaminergic neurotransmit...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.55.10.1460

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Neurology More from this journal
Volume:
55
Issue:
10
Pages:
1460-1467
Publication date:
2000-11-01
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Language:
English
Keywords:
Pubs id:
pubs:242353
UUID:
uuid:adab439f-70dc-4c5f-91bc-48dbf95736ef
Local pid:
pubs:242353
Source identifiers:
242353
Deposit date:
2012-12-19

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