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Constitutive upregulations of titin-based signalling proteins in KY deficient muscles.

Abstract:

An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in ky/ky muscles. Our results indicate that induction of this set ...

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Publisher copy:
10.1016/j.nmd.2006.05.013

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Neuromuscular disorders : NMD More from this journal
Volume:
16
Issue:
7
Pages:
437-445
Publication date:
2006-07-01
DOI:
EISSN:
1873-2364
ISSN:
0960-8966

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