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Constitutive upregulations of titin-based signalling proteins in KY deficient muscles.

Abstract:

An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in ky/ky muscles. Our results indicate that induction of this set ...

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Publisher copy:
10.1016/j.nmd.2006.05.013

Authors


Beatham, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
van der Ven, PF More by this author
Sarparanta, J More by this author
Williams, D More by this author
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Journal:
Neuromuscular disorders : NMD
Volume:
16
Issue:
7
Pages:
437-445
Publication date:
2006-07-05
DOI:
EISSN:
1873-2364
ISSN:
0960-8966
URN:
uuid:ada7734d-327d-4d4d-9a83-9bb5a386091a
Source identifiers:
256157
Local pid:
pubs:256157

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